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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Molecular Mechanisms Determining Mammalian Oocyte Quality: Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance

Molecular Mechanisms Determining Mammalian Oocyte Quality: Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance

Balboula, Ahmed Z.

Paperback

Series: Advances in Anatomy, Embryology and Cell Biology, Book 238

Anatomy & PhysiologyBiologyGenetic Conditions

ISBN10: 3031551621
ISBN13: 9783031551628
Publisher: Springer
Published: Jul 20 2024
Pages: 129
Weight: 0.45
Height: 0.30 Width: 6.14 Depth: 9.21
Language: English

As the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms.

Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome.

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