Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Molecular Dynamics and Optimization Studies of α-Synuclein Protein Structures: Mechanism Underlying the Parkinson's Disease and Movement Disorder

Molecular Dynamics and Optimization Studies of α-Synuclein Protein Structures: Mechanism Underlying the Parkinson's Disease and Movement Disorder

Zhang, Jiapu

Hardcover

Series: Springer Biophysics, Book 29

BiologyCognition

ISBN10: 3032212804
ISBN13: 9783032212801
Publisher: Springer
Published: Jul 13 2026
Language: English
Parkinson's disease (PD), the second most common neurodegenerative disorder in human. The cause of PD is believed to involve genetic factors. At least 6 pathogenic genes have been associated with familial PD. α-Synuclein (αS) is the main component of the Lewy bodies that accumulate in the brains of people with PD. Misfolding of the αS protein has been implicated in the molecular chain of events leading to PD. This book studies wild type (WT) αS proteins and their (8) αS(1-140)-mutants by optimization and Molecular Dynamics (MD). In this book our systematic MD study of a wider range of mutants would provide some answers for genetic factors.

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