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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
The Molecular Biology of Adenoviruses I: 30 Years of Adenovirus Research 1953-1983

The Molecular Biology of Adenoviruses I: 30 Years of Adenovirus Research 1953-1983

Doerfler, W.

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 109

Medical ReferenceBiology

ISBN10: 3642694624
ISBN13: 9783642694622
Publisher: Springer
Published: Dec 7 2011
Pages: 232
Weight: 0.90
Height: 0.53 Width: 6.69 Depth: 9.61
Language: English
A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de- velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo- lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu- dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans- formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea- lized in the late 1960s and the 1970s.

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