Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Molecular Basis of Sex Hormone Receptor Function: New Targets for Intervention

Molecular Basis of Sex Hormone Receptor Function: New Targets for Intervention

Gronemeyer, Hinrich
Fuhrmann, Ulrike
Parczyk, Karsten

Paperback

Series: Ernst Schering Foundation Symposium Proceedings, Book 24

Medical ReferenceBiology

ISBN10: 3662036916
ISBN13: 9783662036914
Publisher: Springer
Published: Oct 3 2013
Pages: 238
Weight: 0.68
Height: 0.54 Width: 5.83 Depth: 8.27
Language: English
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.

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