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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Mechanisms in B-Cell Neoplasia 1990: Workshop 1990 at the National Cancer Institute National Institutes of Health Bethesda, MD, Usa, March 28-30,1990

Mechanisms in B-Cell Neoplasia 1990: Workshop 1990 at the National Cancer Institute National Institutes of Health Bethesda, MD, Usa, March 28-30,1990

Potter, Michael
Melchers, Fritz

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 166

Medical Reference

ISBN10: 3642758916
ISBN13: 9783642758911
Publisher: Springer
Published: Jan 19 2012
Pages: 380
Weight: 1.24
Height: 0.83 Width: 6.14 Depth: 9.21
Language: English
The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza- tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma- tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter- parts of the major forms of human B cell tumors, e. g., follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the experiments in nature to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.

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