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Mechanisms and Mediators of Neuropathic Pain
Hardcover
Series: Progress in Inflammation Research
ISBN13: 9783764362379
Publisher: Springer Nature
Published: Apr 1 2002
Pages: 260
Weight: 1.62
Height: 1.01 Width: 6.70 Depth: 9.36
Language: English
Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences.
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