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Macrophages: Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases

Hardcover

Medical ReferenceAnatomy & Physiology

ISBN10: 1493913107
ISBN13: 9781493913107
Publisher: Springer Nature
Published: Nov 13 2014
Pages: 615
Weight: 2.31
Height: 1.31 Width: 6.14 Depth: 9.21
Language: English

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells.

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