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Local Control of Microvascular Perfusion
Paperback
Series: Colloquium Lectures on Integrated Systems Physiology
Medical ReferenceAnatomy & Physiology
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ISBN10: 1615044361
ISBN13: 9781615044368
Publisher: Morgan & Claypool
Published: Oct 1 2012
Pages: 148
Weight: 0.57
Height: 0.31 Width: 7.50 Depth: 9.25
Language: English
ISBN13: 9781615044368
Publisher: Morgan & Claypool
Published: Oct 1 2012
Pages: 148
Weight: 0.57
Height: 0.31 Width: 7.50 Depth: 9.25
Language: English
Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.
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