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Lupus: Molecular and Cellular Pathogenesis

Lupus: Molecular and Cellular Pathogenesis

Paperback

Series: Contemporary Immunology

Medical Reference

ISBN10: 1475756860
ISBN13: 9781475756869
Publisher: Springer Nature
Published: Mar 24 2013
Pages: 709
Weight: 2.80
Height: 1.70 Width: 6.80 Depth: 9.90
Language: English
Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

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