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612-822-4611
Leucine-Rich Repeat Kinase 2 (Lrrk2)

Leucine-Rich Repeat Kinase 2 (Lrrk2)

Paperback

Series: Advances in Neurobiology, Book 14

Medical ReferenceCognition

ISBN10: 3319842870
ISBN13: 9783319842875
Publisher: Springer
Published: Aug 7 2018
Pages: 271
Weight: 0.91
Height: 0.61 Width: 6.14 Depth: 9.21
Language: English
Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease.- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease.- Clinical features of LRRK2 carriers with Parkinson's disease.- Part II: Fundamentals of LRRK2 Biology.- LRRK2 phosphorylation.- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity.- LRRK2 and autophagy.- Molecular insights and functional implication of LRRK2 dimerization.- LRRK2 and the immune system.- Regulation of LRRK2 by phosphatases.- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options.- Animal models of LRRK2-associated Parkinson's disease.- LRRK2 and the LRRKtosome at the crossroads of programmed cell death: Clues from RIP kinase relatives.- Interaction of LRRK2 and α-synuclein in Parkinson's disease.- Mechanisms of mutant LRRK2 neurodegeneration.- Small molecule inhibitors of LRRK2.

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