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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Ionic Channels in Cells and Model Systems

Ionic Channels in Cells and Model Systems

Latorre, Ramón

Paperback

Series: The Centro de Estudios Científicos

BiologyZoology

ISBN10: 1468450794
ISBN13: 9781468450798
Publisher: Springer Nature
Published: Mar 14 2013
Pages: 437
Weight: 1.36
Height: 0.94 Width: 6.00 Depth: 9.00
Language: English
This book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984. It is intended as a tutorial guide on the properties, function, modulation, and reconstitution of ionic channels, and it should be accessible to graduate students taking their first steps in this field. In the presentation there has been a deliberate emphasis on the spe- cific methodologies used toward the understanding of the workings and function of channels. Thus, in the first section, we learn to read single- channel records: how to interpret them in the theoretical frame of kinetic models, which information can be extracted from gating currents in re- lation to the closing and opening processes, and how ion transport through an open channel can be explained in terms of fluctuating energy barriers. The importance of assessing unequivocally the origin and purity of mem- brane preparations and the use of membrane vesicles and optical tech- niques in the stUGY of ionic channels are also discussed in this section. The patch-clamp technique has made it possible to study ion channels in a variety of different cells and tissues not amenable to more conven- tional electrophysiological methods. The second section, therefore, deals with the use of this technique in the characterization of ionic channels in different types of cells, ranging from plant protoplasts to photoreceptors.

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