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Inflammatory Reaction

Inflammatory Reaction

Paperback

Series: Current Topics in Pathology, Book 68

Medical Reference

ISBN10: 3642673139
ISBN13: 9783642673139
Publisher: Springer Nature
Published: Dec 7 2011
Pages: 298
Weight: 1.09
Height: 0.65 Width: 6.69 Depth: 9.61
Language: English
The morphological behaviour of leucocytes- leaving the blood has been studied for more than a hundred years and can be described in some detail, but the mechanisms involved are for the most part still unclear. Following an inflammatory stimulus, dy- namic changes occur in small blood vessels near the inflamed site and are followed by margination of leucocytes and by their adherence to the endovascular surface of endo- out of the vessel in the gaps between endothelial thelial cells. The leucocytes migrate cells and move towards the noxious stimulus, directed presumably by chemotactic gra- dients. Having reached the gradient source, they may engage in phagocytosis, killing and digestion of micro-organisms or of damaged tissue. In this review, we deal with the adhesive properties of leucocytes, which have US1, l;ll- ly been measured in vitro, and with their possible relevance to the leucocyte-endo- We also deal with the locomotion of leucocytes, its machinery thelial cell interaction.

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