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Valutazione dei parametri immunologici in pazienti affetti da celiachia
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ISBN10: 6207695070
ISBN13: 9786207695072
Publisher: Edizioni Sapienza
Published: Jun 24 2024
Pages: 116
Weight: 0.40
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786207695072
Publisher: Edizioni Sapienza
Published: Jun 24 2024
Pages: 116
Weight: 0.40
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Italian
La celiachia (CD) è un disturbo autoimmune dell'intestino digerente. In questa malattia sono stati inclusi molti test immunologici per spiegare il ruolo del sistema immunitario: anticorpo anti-endomiceliale (EMA), anticorpo anti-transglutaminasi tissutale (tTG), anticorpo anti-acido glutammico decarbossilasi (GAD), interferone gamma (IFN-γ) e interleuchina-10 (IL-10). I risultati hanno rivelato che il livello degli anticorpi EMA, tTG e GAD è diminuito significativamente nei sieri dei pazienti sottoposti a dieta priva di glutine rispetto ai loro livelli nei sieri dei pazienti di nuova diagnosi (sottoposti a dieta con glutine), mentre è stato osservato un aumento significativo dei livelli di IFN-γ e IL-10 dei due gruppi rispetto al gruppo controllato. Lo studio si è concentrato anche sulla relazione tra infezione da rotavirus e CD. Il risultato ha concluso che il rotavirus può essere considerato una delle cause importanti della CD, soprattutto nei bambini di età inferiore ai 10 anni.
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