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Regolatori della trascrizione della famiglia AraC batterica
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ISBN10: 6208868580
ISBN13: 9786208868581
Publisher: Edizioni Sapienza
Published: Jul 4 2025
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786208868581
Publisher: Edizioni Sapienza
Published: Jul 4 2025
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
Il problema sempre crescente della resistenza batterica agli antibiotici richiede lo sviluppo di nuove strategie antimicrobiche. I bersagli molecolari degli antibiotici tradizionali sono processi che agiscono sulla crescita batterica, il che esercita una notevole pressione selettiva sui batteri affinché sviluppino resistenza. Un approccio alternativo che potrebbe ridurre la resistenza batterica consiste nel prendere di mira proteine che non sono necessarie per la sopravvivenza dei batteri, ma che sono necessarie per la virulenza. Le proteine attivatori della trascrizione della famiglia AraC sono i bersagli più adatti, poiché queste proteine non sono essenziali per la crescita batterica, ma sono necessarie per l'espressione di molteplici fattori di virulenza. Il blocco della funzione di questi attivatori della trascrizione ha il potenziale di migliorare la virulenza e la malattia. Le proteine della famiglia AraC sono regolatori della trascrizione definiti da un dominio conservato di legame al DNA e svolgono un ruolo nel metabolismo del carbonio, nelle risposte allo stress e, soprattutto, nella virulenza. Comprendere i meccanismi di regolazione della trascrizione da parte di queste proteine aiuterà nella progettazione razionale di farmaci mirati a queste proteine.
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