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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology

Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology

Lasek, Witold
Zagozdzon, Radoslaw
Jakóbisiak, Marek

Paperback

Series: Springerbriefs in Immunology

Medical ReferenceChemistry

ISBN10: 3319469053
ISBN13: 9783319469058
Publisher: Springer Nature
Published: Oct 6 2016
Pages: 75
Weight: 0.29
Height: 0.17 Width: 6.14 Depth: 9.21
Language: English

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

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