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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Adenosine's Role in Controlling Cmro2 Following Hypoxia-Ischemia

Adenosine's Role in Controlling Cmro2 Following Hypoxia-Ischemia

Ridha Mustafa

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Medical Reference

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ISBN10: 365934818X
ISBN13: 9783659348181
Publisher: Lap Lambert Academic Pub
Published: Feb 18 2013
Pages: 80
Weight: 0.28
Height: 0.19 Width: 6.00 Depth: 9.00
Language: English
The cerebral metabolic rate of oxygen (CMRO2) has been shown to be an early indicator of hypoxia-ischemia (HI); however, the mechanisms controlling post-HI CMRO2 are not clear. One potential mechanism is the activation of the adenosine A1 receptor due to increased adenosine concentrations during the insult. The present study investigated if the specific adenosine A1 antagonist, DPCPX, would reduce the typical reduction in CMRO2 and electrical cortical activity following HI. Measurements of CMRO2 and electrical cortical activity were obtained on piglets by near-infrared spectroscopy (NIRS) and amplitude-integrated electroencephalography (aEEG), respectively. The post-HI measurements of CMRO2 and mean aEEG background voltage were significantly less depressed in piglets treated with DPCPX than controls (p

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