Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Immunopathology of Insulin: Clinical and Experimental Studies

Immunopathology of Insulin: Clinical and Experimental Studies

Federlin, Konrad

Paperback

Series: Monographs on Endocrinology, Book 6

Medical ReferenceBiology

ISBN10: 3642806104
ISBN13: 9783642806100
Publisher: Springer
Published: Dec 15 2011
Pages: 188
Weight: 0.66
Height: 0.44 Width: 6.14 Depth: 9.21
Language: English
Soon after the discovery of insulin in 1922, it became clear that the use of this hormone in the treatment of diabetics is often accom- panied by allergy. In 1956 it became possible to determine quantita- tively the insulin-binding antibodies which are responsible for the resistance to insulin. The methods developed since then make it possible to measure minute amounts of the pancreatic hormone in blood and extracellular fluids. There have been many attempts to relate insulin allergy and in- sulin resistance to the primary, secondary or tertiary structure of the or B chains, or both, and more recently, to the proinsulin which is A present in all commercial preparations of insulin, i. e. to the species- specific structure of the C peptide. In the great majority of papers dealing either with the immunogenic and antigenic properties of in- sulin or with the relevant antibodies, the discussion has been restricted to the humoral antibodies. The existence of a brief period of delayed local allergy resulting from the cellular immune response has more or less escaped attention. It is specifically this period of delayed allergy that attracted the interest of Dr. FEDERLIN and his colleagues. Making use of immuno- histological and other techniques which are rarely employed in clinical observation, and with the help of experiments on animals, Dr. FEDERLIN traces the course of insulin allergy from cellular immunity, through the production of humoral antibodies by the insulin-binding cells of the circulation, to the sessile immunological apparatus.

Also in

Medical Reference

View All