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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Immunobiology of Natural Killer Cell Receptors

Immunobiology of Natural Killer Cell Receptors

Vivier, Eric
Colonna, Marco

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 298

Medical Reference

ISBN10: 3642065457
ISBN13: 9783642065453
Publisher: Springer Nature
Published: Feb 12 2010
Pages: 284
Weight: 0.91
Height: 0.64 Width: 6.13 Depth: 9.14
Language: English

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

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