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Immunobiology of Bacterial Cpg-DNA

Immunobiology of Bacterial Cpg-DNA

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 247

Medical ReferenceBiology

ISBN10: 364264077X
ISBN13: 9783642640773
Publisher: Springer Nature
Published: Sep 26 2011
Pages: 246
Weight: 0.82
Height: 0.55 Width: 6.14 Depth: 9.21
Language: English
Bacterial CpG-DNA sequences not only serve for genetic information but act as danger signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as natural adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.

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