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Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing: A Big Chapter in the Tale

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing: A Big Chapter in the Tale

Hardcover

Medical ReferenceGenetics

ISBN10: 3030538206
ISBN13: 9783030538200
Publisher: Springer Nature
Published: Sep 29 2020
Pages: 185
Weight: 1.02
Height: 0.50 Width: 6.14 Depth: 9.21
Language: English

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC.

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