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Histone Mutations and Cancer

Histone Mutations and Cancer

Hardcover

Series: Advances in Experimental Medicine and Biology, Book 1283

Medical ReferenceChemistry

ISBN10: 9811581037
ISBN13: 9789811581038
Publisher: Springer Nature
Published: Nov 7 2020
Pages: 96
Weight: 0.90
Height: 0.31 Width: 7.00 Depth: 10.00
Language: English
This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones.

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