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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation

The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation

Daachi, Fares
Adi-Bessalem, Sonia

Paperback

Biology

ISBN10: 6208905176
ISBN13: 9786208905170
Publisher: Our Knowledge Publishing
Published: May 29 2025
Pages: 144
Weight: 0.44
Height: 0.34 Width: 6.00 Depth: 9.00
Language: English
Thehypothalamic-pituitary-adrenal(HPA)axis is a key player in the interaction between the neuroendocrine and immune systems. This study explores the impact ofAndroctonus australis hector(Aah) venom on HPA axis activation, as a function of day-night phases. Using an experimental approach, we analyze the inflammatory responses and oxidative damage induced by envenomation, highlighting the modulation exerted by corticosterone. Increased serum levels of ACTH and corticosterone indicate increased activation of the HPA, most marked during the active phase. At the same time, venom causes oxidative damage and cardio-hepatic alterations, amplified by excessive production of reactive oxygen and nitrogen species. The involvement of corticosterone in these disturbances was assessed using a dexamethasone suppression test. These results highlight an inflammatory and metabolic response modulated by circadian rhythms, underlining the importance of the HPA in the management of toxic stress.

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