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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Histophysiology of the Circulating Platelet

Histophysiology of the Circulating Platelet

Wurzinger, Laurenz J.

Paperback

Series: Advances in Anatomy, Embryology and Cell Biology, Book 120

Medical ReferenceAnatomy & Physiology

ISBN10: 3540522581
ISBN13: 9783540522584
Publisher: Springer
Published: Jun 29 1990
Pages: 96
Weight: 0.41
Height: 0.22 Width: 6.69 Depth: 9.61
Language: English
1. 1 Platelets in Hemostasis and Thrombosis: A Brief Overview For more than 100 years the dominant role of blood platelets in hemostasis and thrombosis has been well documented. Seven years before their identification as a distinct class of blood corpuscles by Bizzozero (1882), Zahn (1875), using intravital microscopic observations, described the growth of an arterial thrombus as the result of continued apposition of colorless blood corpuscles along the direction of blood flow. A hallmark still valid today was set by Eberth and Schimmel busch (1888), who clearly divided the formation of the hemostatic plug into the result of the conglutination of preformed blood corpuscles, followed by the plasmatic coagulation as the formation of fibrin from substances dissolved in blood, as two distinct processes taking place in the described order. In spite of technical shortcomings, by approaching the limits of the light microscopic techniques of their time, Eberth and Schimmel busch discovered a change in the morphology of the platelets, paralleled by a presumptive change in their functional state, which was a prerequisite for the formation of a platelet plug. Their meticulous description implicitly anticipated the modern terminology of the smooth disk as the resting form of the circulating platelet and the activated spiny sphere as a result of a change in shape following stimulation.

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