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Hereditary Colorectal Cancer: Genetic Basis and Clinical Implications
Paperback
ISBN13: 9783030089481
Publisher: Springer Nature
Published: Jan 26 2019
Pages: 505
Weight: 1.58
Height: 1.04 Width: 6.14 Depth: 9.21
Language: English
Part1: GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome.- The molecular basis of Lynch-like syndrome.- Constitutional mismatch repair deficiency.- Mismatch repair proficient hereditary non-polyposis colorectal cancer.- Genetic and environmental modifiers of risk in Lynch syndrome.- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction.- Familial adenomatous polyposis.- Polymerase proofreading-associated polyposis.- MUTYH-associated polyposis.- NTHL1-associated polyposis.- Germline biallelic inactivation of MMR genes (with polyposis phenotype).- Unexplained adenomatous polyposis.- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome.- Juvenile polyposis syndrome.- PTEN-hamartoma tumor syndromes.- Other hamartomatous polyposis conditions.- HEREDITARY MIXED POLYPOSIS SYNDROME.- SERRATED POLYPOSIS SYNDROME.- Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT.- Genetic testing in hereditary colorectal cancer.- Universal tumor screening for Lynch syndrome.- Classification of genetic variants. Prediction models for Lynch syndrome.- Surveillance guidelines for hereditary colorectal cancer syndromes.- Surgical management of hereditary colorectal cancer syndromes.- Chemoprevention in hereditary colorectal cancer syndromes.- Immunotherapy in hereditary colorectal cancer.- The Immune Biology of Microsatellite Unstable cancer.- Hereditary colorectal cancer: Immunotherapy approaches.- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES.- Databases: intentions, capabilities and limitations.- The Colon Cancer Family Registry Cohort.- The Prospective Lynch Syndrome Database.- The InSiGHT Database: An example LOVD system.- The International Mismatch Repair Consortium.
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