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Genetic Disorders of Human Sexual Development

Genetic Disorders of Human Sexual Development

Hardcover

Series: Oxford Monographs on Medical Genetics, Book 38

Medical ReferenceSexuality

ISBN10: 0195109074
ISBN13: 9780195109078
Publisher: Oxford University Press
Published: Jun 17 1999
Pages: 432
Weight: 2.10
Height: 1.23 Width: 7.28 Depth: 10.36
Language: English
There have been many exciting advances in our understanding of mammalian sex determination and differentiation in the last decade. Using these advances to elucidate clinical conditions of abnormal sexual development, the authors bring together great expertise in molecular endocrinology, molecular genetics, and dysmorphology. The text begins with a discussion of normal gonadal and sexual development that presents enough embryology, biochemistry, and endocrinology to make the remaining chapters easy to assimilate. Then the authors discuss overarching clinical issues that are common to genetic abnormalities of gonadal and sexual development, providing a detailed account of genetic causes of gonadal maldevelopment, followed by a compendium of the singular, syndromal, endocrinologic, and systemic-metabolic genetic causes of sexual maldevelopment. The final section describes genetic forms of gamete failure.

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