Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Gpcr Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity

Gpcr Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity

Dupré, Denis J.
Hébert, Terence E.
Jockers, Ralf

Paperback

Series: Subcellular Biochemistry, Book 63

Medical ReferenceChemistry

ISBN10: 9401780994
ISBN13: 9789401780995
Publisher: Springer Nature
Published: Dec 14 2014
Pages: 300
Weight: 0.96
Height: 0.65 Width: 6.14 Depth: 9.21
Language: English
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

1 different editions

Also available

Also in

Medical Reference

View All