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Glycoproteins and Human Disease

Glycoproteins and Human Disease

Paperback

Series: Medical Intelligence Unit (Unnumbered)

Medical ReferenceBiology

ISBN10: 366221962X
ISBN13: 9783662219621
Publisher: Springer Nature
Published: Apr 17 2014
Pages: 242
Weight: 1.01
Height: 0.55 Width: 7.00 Depth: 10.00
Language: English
Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the oligosaccharide assembly by glycosyltransferases. This volume reviews several mechanisms that may underly the extremely complex alterations in disease. Disease specific glycosylation may contribute to the disease process by altering cellular functions, or may be exploited therapeutically. Specific therapy may be aimed at correcting glycosylation abnormalities based on knowledge of the mechanisms leading to the disease phenotype and the three-dimensional interactions between carbohydrates and carbohydrate-binding molecules.

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