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Dexamethason bei der Transdifferenzierung von Pankreasknospen
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ISBN10: 6208544610
ISBN13: 9786208544614
Publisher: Verlag Unser Wissen
Published: Jan 16 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208544614
Publisher: Verlag Unser Wissen
Published: Jan 16 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: German
Transdifferenzierung ist definiert als die direkte Umwandlung eines differenzierten Zelltyps in einen anderen. Normalerweise findet Transdifferenzierung in Zellen statt, die aus benachbarten Zellen im sich entwickelnden Embryo stammen. Transdifferenzierung kann auch experimentell durch Überexpression der Expression von Master-Switch-Genen oder eines einzelnen Transkriptionsfaktors ausgelöst werden. Ein Beispiel für die Transdifferenzierung sind zwei endodermal abgeleitete Gewebe, Leber und Bauchspeicheldrüse: Leber und Bauchspeicheldrüse stammen aus der gleichen Region des Endoderms, und ihr Transdifferenzierungsphänomen wurde in einigen Studien wie den Experimenten von Rao und Reddy beobachtet. Kürzlich haben Forscher die Transdifferenzierung von Bauchspeicheldrüsenzellen in Leberzellen unter Verwendung eines synthetischen Glukokortikoids, Dexamethason (Dex), nachgewiesen. Wir wollten die Transdifferenzierung von embryonalen Pankreaszellen zu hepatozytenähnlichen Zellen mit Hilfe des synthetischen Glukokortikoids Dex untersuchen. Wir isolierten dorsale Pankreasknospen aus E11,5d-Embryonen und kultivierten sie in Abwesenheit und Anwesenheit von Dex.
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