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Formulation Development of Extended Released Rifaximin Micro-particles

Formulation Development of Extended Released Rifaximin Micro-particles

Paperback

Medical Reference

ISBN10: 3659418404
ISBN13: 9783659418402
Publisher: Lap Lambert Academic Pub
Published: Mar 10 2015
Pages: 128
Weight: 0.44
Height: 0.30 Width: 6.00 Depth: 9.00
Language: English
This book addresses the formulation and process design aspects of extended release micro particles of BCS class IV drug Rifaximin through cyclodextrin complexation and extending the drug release by Eudragit L -100 enteric coating. The concept of surface response methodology was used in the selection of optimized batch that was further evaluated for various parameters. The data supports an improvement in aqueous solubility of BCS class IV drugs through cyclodextrin complexes. The release of such inclusion complexes can be retarded for 8 hrs by enteric coating.

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Medical Reference