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Fluoropyrimidines in Cancer Therapy

Fluoropyrimidines in Cancer Therapy

Paperback

Series: Cancer Drug Discovery & Development

Medical Reference

ISBN10: 1617372749
ISBN13: 9781617372742
Publisher: Springer Nature
Published: Nov 19 2010
Pages: 326
Weight: 1.30
Height: 0.71 Width: 7.00 Depth: 10.00
Language: English
Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of thymidylate synthase inhibitors. The authors discuss the potential advantages and disadvantages of these varied drugs and their mode of administration. Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.

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