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Virulence de Candida tropicalis Etude expérimentale
Paperback
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ISBN10: 6206713458
ISBN13: 9786206713456
Publisher: Editions Universitaires Europeennes
Published: Jan 10 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786206713456
Publisher: Editions Universitaires Europeennes
Published: Jan 10 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
Candida tropicalis est l'une des espèces de C. non albicans les plus redoutables au monde (3 à 66% des isolats). L'objectif de l'étude était d'évaluer la virulence in vivo d'une souche tellurique de C. tropicalis selon le modèle G. mellonella. Cette étude a été réalisée au Burkina Faso.Il s'est agi d'une étude prospective expérimentale. Des lots de 10 larves de 280 à 320mg et une souche tellurique de C. tropicalis identifiée au MALDI-TOF ont été utilisés. Les larves ont été inoculées avec 20μl de suspension fongique à concentrations croissantes de 5.105, 1.106, et 5.106 UFC. Un groupe témoin a été injecté avec 20μL de PBS stérile. La mélanisation et la mort larvaire ont été observées/24H sur 12 jours.Au total, 100% des larves se sont mélanisées 30 mn après inoculation aux concentrations 1.106, et 5.106 UFC/larve et la mortalité était de 100% à H48 (p
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