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La séricine de soie comme composé neuroprotecteur contre la maladie d'Alzheimer chez le rat
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ISBN10: 6206423042
ISBN13: 9786206423041
Publisher: Ed Notre Savior
Published: Sep 5 2023
Pages: 192
Weight: 0.64
Height: 0.44 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786206423041
Publisher: Ed Notre Savior
Published: Sep 5 2023
Pages: 192
Weight: 0.64
Height: 0.44 Width: 6.00 Depth: 9.00
Language: French
Ce livre traite de l'induction de la maladie d'Alzheimer chez le rat et de l'extraction de la protéine de soie et de la séricine des cocons de soie. Les expériences se sont concentrées sur des études morphométriques, comportementales et biochimiques, notamment sur le système cholinergique et le système antioxydant, ainsi que sur des études histopathologiques portant sur des régions sélectionnées du cerveau du rat. Enfin, les résultats invivo ont été corrélés avec l'approche bioinformatique. Les résultats de nos recherches ont révélé que les protéines de soie et la séricine avaient des effets positifs sur le poids corporel, les capacités d'apprentissage et la mémoire (cognitive) des rats induits par la maladie d'Alzheimer. Il est évident que la séricine a exercé des propriétés AChE chez les rats induits par la MA en augmentant les niveaux d'ACh et en inhibant l'activité AChE dans toutes les régions sélectionnées du cerveau des rats. La séricine a montré une activité antioxydante en augmentant les niveaux de SOD et de CAT et en diminuant les niveaux de GR et de MDA chez les rats atteints de la maladie d'Alzheimer. Les résultats ci-dessus ont été fortement étayés par des études histologiques et bioinformatiques. Il est évident que les changements induits par la maladie d'Alzheimer ont été inversés en traitant les rats avec de la séricine sur une exposition à long terme.
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