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Protéine HSP70: marqueur diagnostique potentiel de l'infection à W. bancrofti
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ISBN10: 6209205720
ISBN13: 9786209205729
Publisher: Editions Notre Savoir
Published: Nov 4 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209205729
Publisher: Editions Notre Savoir
Published: Nov 4 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
La filariose lymphatique (FL), une maladie parasitaire transmise par les moustiques et causée par les espèces Wuchereria bancrofti et Brugia, est l'une des maladies tropicales les plus répandues et pourtant les plus négligées, avec de graves conséquences économiques et sociales. Le stade microfilarémique asymptomatique étant considéré comme l'un des obstacles à l'élimination mondiale de la FL, la ScHSP70 pourrait être un agent prometteur pour l'immunodiagnostic. De plus, en raison de l'indisponibilité de W. bancrofti et B. malayi, le parasite filarien bovin S. cervi peut être une bonne source d'antigènes hétérologues pouvant être explorés comme candidats potentiels pour le diagnostic, la chimiothérapie et les vaccins. L'analyse protéomique est très utile pour caractériser ScHSP70 comme une protéine associée à la maladie, bien que la protéomique ait été réalisée sur une petite cohorte. Les résultats obtenus dans cette étude sont prometteurs, mais des études supplémentaires sur l'expression recombinante sont nécessaires pour déterminer sa précision diagnostique dans l'immunodiagnostic de la filariose lymphatique dans une zone endémique. Cette étude ouvre également la possibilité d'explorer les protéines de choc thermique pour leur utilisation dans le diagnostic d'autres maladies helminthiques.
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