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Fusion vésiculaire, importation de protéines et clivage protéolytique chez les eucaryotes
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ISBN10: 6209462227
ISBN13: 9786209462221
Publisher: Editions Notre Savoir
Published: Jan 12 2026
Pages: 164
Weight: 0.50
Height: 0.38 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209462221
Publisher: Editions Notre Savoir
Published: Jan 12 2026
Pages: 164
Weight: 0.50
Height: 0.38 Width: 6.00 Depth: 9.00
Language: French
Cette publication présente les travaux d'une thèse de recherche qui a apporté une contribution majeure à la compréhension actuelle du trafic intracellulaire des protéines dans deux domaines importants: la fusion vésiculaire et la biogenèse des peroxysomes. Ces travaux ont débuté par une étude des SNARE, des protéines hautement conservées qui constituent le mécanisme central de fusion au sein des systèmes de transport sécrétoire et endosomal, décrivant les premières découvertes concernant la régulation d'un membre intégral de ce mécanisme protéique, la syntaxine 5, par le biais de son partenaire de liaison protéique rSly1 dans le réticulum endoplasmique/Golgi Sec1/Munc18 des mammifères. Cette recherche s'est poursuivie par l'examen de l'importation des protéines matricielles des peroxysomes, un mode de transport des protéines qui utilise deux signaux de ciblage peroxysomaux distincts (PTS1 et 2). Ces études se sont spécifiquement concentrées sur l'identification de la protéase de traitement PTS2. De plus, deux protéines d'Arabidopsis thaliana possédant à la fois les signaux PTS1 et PTS2 présumés ont été examinées. Ainsi, grâce à des techniques de biologie cellulaire et moléculaire, cette recherche a élargi le domaine du trafic intracellulaire des protéines.
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