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Détection de la rigidité de la matrice extracellulaire et réponse cellulaire
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ISBN10: 6209702155
ISBN13: 9786209702150
Publisher: Editions Notre Savoir
Published: Mar 9 2026
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209702150
Publisher: Editions Notre Savoir
Published: Mar 9 2026
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: French
Cet ouvrage se concentre sur les réponses à la rigidité de la matrice chez les neurones et les fibroblastes. Les exigences spécifiques en matière de rigidité de la matrice dans différents types de cellules ont été corrélées à la rigidité de leurs tissus natifs in vivo. Alors que les fibroblastes se propagent sur des zones plus vastes sur des substrats rigides que sur des substrats mous, les substrats mous stimulent l'élongation et la ramification des axones dans les neurones primaires. Dans nos études, nous avons décrit une voie de réponse à la rigidité spécifique à la fibronectine, présente à la fois dans les fibroblastes et les neurones. Bien que les neurones réagissent à la rigidité de la FN de manière opposée aux fibroblastes, nous suggérons que le mécanisme de détection de la rigidité de la FN est similaire et implique le recrutement de Fyn par RPTPα en fonction de la rigidité, puis la phosphorylation de la tyrosine p130Cas. Une fois phosphorylée, la p130Cas pourrait envoyer des signaux à diverses voies qui favorisent normalement la croissance et non la différenciation.
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