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Composés naturels et nanoformulations pour les lésions rénales au cisplatine
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ISBN10: 6208897831
ISBN13: 9786208897833
Publisher: Editions Notre Savoir
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208897833
Publisher: Editions Notre Savoir
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: French
Les lésions rénales aiguës induites par le cisplatine restent un défi clinique majeur en raison de leur pathogénie multifactorielle impliquant le stress oxydatif, l'inflammation, l'apoptose et la fibrose. De plus en plus de preuves confirment le potentiel néphroprotecteur de composés naturels tels que l'huile de germe de blé, Moringa oleifera, Ficus carica, le resvératrol, les acides gras polyinsaturés oméga-3 et la curcumine. Ces agents présentent des propriétés antioxydantes, anti-inflammatoires, anti-apoptotiques et anti-fibrotiques par le biais de mécanismes comprenant l'activation de la voie Nrf2, l'inhibition de NF-κB et des cytokines pro-inflammatoires, et la préservation de l'architecture rénale. Une efficacité accrue a été obtenue grâce à des systèmes d'administration basés sur la nanotechnologie, tels que les nanoémulsions, les nanoparticules d'or et les supports recouverts d'AH, qui améliorent la biodisponibilité et le ciblage rénal. Collectivement, ces composés naturels, en particulier sous forme de nanoparticules, offrent une approche thérapeutique prometteuse, sûre et multicible pour atténuer l'insuffisance rénale aiguë induite par le cisplatine sans compromettre ses effets antitumoraux, ce qui justifie un examen clinique plus approfondi.
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