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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Formulation and Evaluation of Mucoadhesive Drug Delivery Systems

Formulation and Evaluation of Mucoadhesive Drug Delivery Systems

Kulkarni, Gururaj S.
A. S., Ankithasirinayana
Choudhary, Vikram T.

Paperback

Medical Reference

ISBN10: 620960692X
ISBN13: 9786209606922
Publisher: LAP Lambert Academic Publishing
Published: Mar 3 2026
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: English
Buccal drug delivery bypasses hepatic first-pass metabolism, offering improved bioavailability over conventional oral administration. This work presents the formulation and evaluation of mucoadhesive buccal tablets of Salbutamol sulphate using natural polymers-Xanthan gum, Guar gum, and Sodium alginate.FTIR and DSC studies confirmed drug-excipient compatibility. Thirty formulations prepared by direct compression, with Ethyl cellulose as a backing layer, met all standard physicochemical parameters. In-vitro dissolution showed up to 100.81% drug release over 8 hours following zero-order kinetics. In-vivo studies on rabbits confirmed 87.37% buccal absorption with sustained plasma levels and higher AUC than oral administration. Good in-vitro/in-vivo correlation and three-month stability were demonstrated.These results establish mucoadhesive buccal tablets as an effective, stable, and bioavailable dosage form for asthma management.

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