Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Final dissertation

Final dissertation

Benabdellah, Karima
Meghni, Chabha
Kessal, Fatma

Paperback

Medical Reference

ISBN10: 6207636155
ISBN13: 9786207636150
Publisher: Our Knowledge Publishing
Published: Jun 11 2024
Pages: 60
Weight: 0.22
Height: 0.14 Width: 6.00 Depth: 9.00
Language: English
Molecular monitoring of BCR-ABL transcript levels by quantitative PCR is increasingly used to assess patient response to treatment. This has become particularly interesting in the imatinib era when residual disease falls below the detection threshold of conventional cytogenetics. The main objective of our work is to study the evolution of CML by quantifying the BCR/ABL molecular transcript during the therapeutic phase. This is a retrospective, descriptive study of 30 patients followed in the hematology department of Tizi Ouzou University Hospital, in the consultation unit. Molecular follow-up showed that 70% of patients achieved MMR with imatinib 400 mg, and 20% of patients who failed imatinib 400 and 600 mg were substituted with a second-generation TKI with 100% MMR. Quantification of the BCR/Abl ratio showed that 96% of patients on imatinib 400mg were cured. In conclusion, optimizing treatment and using the various TKIs available requires biomolecular monitoring of BCR/Abl transcripts right from diagnosis.

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