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Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
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612-822-4611
Fibrous Dysplasia and Beyond: Understanding Fibro-Osseous Jaw Lesions

Fibrous Dysplasia and Beyond: Understanding Fibro-Osseous Jaw Lesions

Paperback

Medical Reference

ISBN10: 6208429633
ISBN13: 9786208429638
Publisher: LAP Lambert Academic Publishing
Published: Feb 12 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: English
Fibro-osseous lesions (FOLs) of the jaws represent a spectrum of disorders characterized by the pathological substitution of normal bone with fibrous connective tissue and mineralized deposits. These entities encompass fibrous dysplasia (FD), cemento-osseous dysplasias (COD), and ossifying fibromas (OF), each demonstrating overlapping yet distinct clinical and radiographic profiles.Fibrous dysplasia, attributed to GNAS-1 gene mutations, manifests as an insidious, painless expansion of affected bones, resulting in facial asymmetry and dental malocclusion. Radiographically, it exhibits a characteristic ground-glass opacity. Therapeutic approaches range from conservative observation to bisphosphonate administration and surgical intervention in cases of significant functional or aesthetic compromise.Cemento-osseous dysplasias, comprising periapical, focal, and florid variants, arise from periodontal ligament progenitor cells. These lesions, predominantly affecting middle-aged women, exhibit a well-defined progression from radiolucency to sclerosis. Typically asymptomatic, they necessitate intervention only in instances of secondary infection.

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Medical Reference