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Experimental Neurotoxicology Methods
Paperback
Series: Neuromethods, Book 172
Please select the version of book you would like to purchase.
ISBN10: 1071616390
ISBN13: 9781071616390
Publisher: Humana
Published: Jul 25 2022
Pages: 491
Weight: 1.94
Height: 1.03 Width: 7.00 Depth: 10.00
Language: English
ISBN13: 9781071616390
Publisher: Humana
Published: Jul 25 2022
Pages: 491
Weight: 1.94
Height: 1.03 Width: 7.00 Depth: 10.00
Language: English
Preface to the Series...
Preface...
Table of Contents...
Contributing Authors...
Rosario Moratalla, Adrián Sanz-Magro, and Noelia Granado 2. Assessment of Auditory Hair Cell Loss by Cytocochleograms
Aurélie Thomas, Thomas Venet, and Benoît Pouyatos 3. Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofluorescent Staining and Confocal Microscopy
Alberto F. Maroto, Erin A. Greguske, Alejandro Barrallo-Gimeno, and Jordi Llorens 4. Morphometric Analysis of Axons and Dendrites as a Tool for Assessing Neurotoxicity
Rhianna K. Morgan, Martin Schmuck, Ana Cristina Grodzki, Donald A. Bruun, Lauren E. Matelski, and Pamela J. Lein Part II Physiological Evaluation in Rodents 5. DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Rat
Thomas Venet, Aurélie Thomas, Ludivine Wathier, and Benoît Pouyatos 6. Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats following Neurotoxicant Exposures
William K. Boyes 7. Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy
Susanna Park, Cynthia L. Renn, Justin G. Lees, Susan G. Dorsey, Guido Cavaletti, and Valentina A. Carozzi Part III Behavioral Evaluation in Rodents 8. The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities
David V. Gauvin 9. Behavioral Assessment of Vestibular Dysfunction in Rats
Alberto F. Maroto, Erin A. Greguske, Meritxell Deulofeu, Pere Boadas-Vaello, and Jordi Llorens 10. Assessment of Olfactory Toxicity in Dodents
David C. Dorman and Melanie L. Foster 11. Assessment of Neurotoxicant-Induced Changes in Behavior: Issues Related to Interpretation of Outcomes and Experimental Design
Deborah A. Cory-Slechta, Katherine Harvey, and Marissa Sobolewski Part IV Molecular Methods 12. Assessment of Neurofilament Light Protein as a Serum Biomarker in Rodent Models of Toxic-Induced Peripheral Neuropathy
Giulia Fumagallia, Guido Cavalettia, Henrik Zetterberg, and Cristina Meregallia 13. Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunostaining of Microglia Morphology
Christopher A. McPherson and G. Jean Harry 14. Mitochondrial Stress Assay and Glycolytic Rate Assay in Microglia using Agilent Seahorse Extracellular Flux Analyzers
Gabrielle Childers and G. Jean Harry Part V Alternative Model Organism-Based Methods 15. Assessment of Larval Zebrafish Locomotor Activity for Developmental Neurotoxicity Screening
Bridgett N. Hill, Kayla D. Coldsnow, Deborah L. Hunter, Joan M. Hedge, David Korest, Kimberly A. Jarema, and Stephanie Padilla 16. A Behavioral Test Battery to Assess Larval and Adult Zebrafish after Developmental Neurotoxic Exposure
Andrew B. Hawkey, Zade Holloway, and Edward D. Levin 17. Evaluation of Neurotoxic Effects in Zebrafish Embryos by Automatic Measurement of Early Motor Behaviors
Elisabet Teixidó, Nils Klüver, Afolarin O. Ogungbemi, Eberhard Küster, and Stefan Scholz 18. Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans
Omamuyovwi M. Ijomone, Priscila Gubert, Comfort O. A. Okoh, Alexandre M. Varão, Leandro de O. Amara, Oritoke M. Aluko, and Michael Aschner Part VI In Vitro Methods 19. Effects of Neurotoxic or Pro-Regenerative Agents on Motor and Sensory Neurite Outgrowth in Spinal Cord Organotypic Slices and DRG Explants in Culture
Sara Bolivar, Ilary Allodi, Mireia Herrando, and
Alberto F. Maroto, Erin A. Greguske, Alejandro Barrallo-Gimeno, and Jordi Llorens 4. Morphometric Analysis of Axons and Dendrites as a Tool for Assessing Neurotoxicity
Rhianna K. Morgan, Martin Schmuck, Ana Cristina Grodzki, Donald A. Bruun, Lauren E. Matelski, and Pamela J. Lein Part II Physiological Evaluation in Rodents 5. DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Rat
Thomas Venet, Aurélie Thomas, Ludivine Wathier, and Benoît Pouyatos 6. Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats following Neurotoxicant Exposures
William K. Boyes 7. Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy
Susanna Park, Cynthia L. Renn, Justin G. Lees, Susan G. Dorsey, Guido Cavaletti, and Valentina A. Carozzi Part III Behavioral Evaluation in Rodents 8. The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities
David V. Gauvin 9. Behavioral Assessment of Vestibular Dysfunction in Rats
Alberto F. Maroto, Erin A. Greguske, Meritxell Deulofeu, Pere Boadas-Vaello, and Jordi Llorens 10. Assessment of Olfactory Toxicity in Dodents
David C. Dorman and Melanie L. Foster 11. Assessment of Neurotoxicant-Induced Changes in Behavior: Issues Related to Interpretation of Outcomes and Experimental Design
Deborah A. Cory-Slechta, Katherine Harvey, and Marissa Sobolewski Part IV Molecular Methods 12. Assessment of Neurofilament Light Protein as a Serum Biomarker in Rodent Models of Toxic-Induced Peripheral Neuropathy
Giulia Fumagallia, Guido Cavalettia, Henrik Zetterberg, and Cristina Meregallia 13. Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunostaining of Microglia Morphology
Christopher A. McPherson and G. Jean Harry 14. Mitochondrial Stress Assay and Glycolytic Rate Assay in Microglia using Agilent Seahorse Extracellular Flux Analyzers
Gabrielle Childers and G. Jean Harry Part V Alternative Model Organism-Based Methods 15. Assessment of Larval Zebrafish Locomotor Activity for Developmental Neurotoxicity Screening
Bridgett N. Hill, Kayla D. Coldsnow, Deborah L. Hunter, Joan M. Hedge, David Korest, Kimberly A. Jarema, and Stephanie Padilla 16. A Behavioral Test Battery to Assess Larval and Adult Zebrafish after Developmental Neurotoxic Exposure
Andrew B. Hawkey, Zade Holloway, and Edward D. Levin 17. Evaluation of Neurotoxic Effects in Zebrafish Embryos by Automatic Measurement of Early Motor Behaviors
Elisabet Teixidó, Nils Klüver, Afolarin O. Ogungbemi, Eberhard Küster, and Stefan Scholz 18. Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans
Omamuyovwi M. Ijomone, Priscila Gubert, Comfort O. A. Okoh, Alexandre M. Varão, Leandro de O. Amara, Oritoke M. Aluko, and Michael Aschner Part VI In Vitro Methods 19. Effects of Neurotoxic or Pro-Regenerative Agents on Motor and Sensory Neurite Outgrowth in Spinal Cord Organotypic Slices and DRG Explants in Culture
Sara Bolivar, Ilary Allodi, Mireia Herrando, and
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