Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Exercise and the Ischemic Brain

Exercise and the Ischemic Brain

Ploughman, Michelle

Paperback

Medical Reference

ISBN10: 3639152697
ISBN13: 9783639152692
Publisher: Blues Kids Of Amer
Published: May 19 2009
Pages: 120
Weight: 0.41
Height: 0.28 Width: 6.00 Depth: 9.00
Language: English
Stroke is one of the leading causes of disability and the hemiplegic upper extremity is particularly resistant to rehabilitation intervention. Endurance exercise, outside of its beneficial effects on the cardiovascular and musculoskeletal systems, influences brain remodelling, learning, and memory. In our experiments, we determined the effects of exercise on critical mediators of neuroplasticity (brain-derived neurotrophic factor (BDNF), insulin- like growth factor (IGF-I), synapsin-I, phosphorylated cyclic AMP response element binding protein (pCREB) and serum corticosterone) in a rat model of middle cerebral artery stroke. It was clear the intensity and duration of exercise had differential effects on proteins that affect neuroplasticity after stroke. Furthermore, animals receiving running exercise preceding a skilled reaching task recovered better than animals that did not. Endurance exercise appears to have an enhancing effect on learning of a subsequent reaching skill mediated in part by structural changes within the brain. This phenomenon may be beneficial when arranging therapeutic activities during stroke rehabilitation.

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