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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Essential Concepts in Toxicogenomics

Essential Concepts in Toxicogenomics

Mendrick, Donna L.
Mattes, William B.

Paperback

Series: Methods in Molecular Biology, Book 460

Medical ReferenceGeneral ScienceGenetics

ISBN10: 1617376884
ISBN13: 9781617376887
Publisher: Springer Nature
Published: Nov 19 2010
Pages: 277
Weight: 0.93
Height: 0.63 Width: 6.14 Depth: 9.21
Language: English
The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook.Instead, wechose to identify experts in all aspects of this field and challenged them to write reviews, opinion pieces, and case studies. This book covers the main areas important to the study and use of toxicogenomics. Chapter 1 speaks to the convergenceofclassicapproachesalongsidetoxicogenomics.Chapter2deals withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity. Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics experiments, as well as the implications of using microarrays as diagnostic devices. The need for appropriate statistical approaches to genomic data is discussed in Chapter 4, and Chapters 5 and 6 describe the use of genomic datatobuildtoxicogenomicmodelsandprovideinsightsfromtheapproaches oftwocompanies.Theimportanttopicofstoringthedatageneratedinsuch experiments and the correct annotation that must accompany such data is considered in Chapter 7. The discussion in Chapter 8 speaks to the use of toxicogenomicstoidentifyspeciessimilaritiesanddifferences.Chapters9and 10dealwiththeuseofgenomicstoidentifybiomarkerswithinthepreclinical andclinicalarenas.Biomarkerswillonlybeusefulifthecommunityatlarge acceptsthemasmeaningful.Consortiaareimportanttodrivethisfunction, and Chapter11discussescurrenteffortsinthisarea.Lastbutnotleast, Chapter12 presentsaperspectiveontheregulatoryimplicationsoftoxicogenomicdataand someofthehurdlesthatcanbeseeninitsimplicationinGLPstudies.Although thisbooktendstofocusonpharmaceuticals, theissuesfacingtoxicologyare sharedbythechemicalmanufacturers, thetobaccoindustry, andtheirregulators. We want to thank our contributors for their generous time and energy in providingtheirinsights.Sadly, wemustnotetheunexpectedpassingofone ofourauthors, Dr.JosephHackettoftheFDA.Joe'scontributionservesasa testimonytohisaccomplishmentsinthisfield, andhisinsightwillbemissed intheyearstocome.

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