Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Epithelial-Mesenchymal Transition: Cancer's Pathway to Spread

Epithelial-Mesenchymal Transition: Cancer's Pathway to Spread

Kashyap, Nikita
Ray, Jay Gopal
S, Aravindan

Paperback

Medical Reference

ISBN10: 6208422051
ISBN13: 9786208422059
Publisher: LAP Lambert Academic Publishing
Published: Mar 21 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: English
Epithelial-mesenchymal transition (EMT) is a vital biological process in which epithelial cells transform into mesenchymal cells, gaining migratory and invasive capabilities. This reversible process plays a critical role in embryonic development, wound healing, fibrosis, and cancer metastasis. EMT is regulated by key signaling pathways, including TGF-β, Wnt, and Notch, and orchestrated by transcription factors like Snail and Twist. In cancer, EMT facilitates invasion, metastasis, and therapy resistance, marking it as a significant factor in tumor progression. EMT also contributes to cancer stem cell formation and immune evasion. The interplay between EMT and mesenchymal-to-epithelial transition (MET) underscores cellular plasticity in metastasis, where cells revert to epithelial states in secondary sites. Recent advances in targeting EMT therapeutically-such as inhibitors of TGF-β and EMT transcription factors-offer hope for reducing metastasis and improving treatment outcomes. This work explores the molecular mechanisms and clinical implications of EMT, emphasizing its dual roles in physiology and pathology.

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