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Effects of Ionizing Radiation in Cancer Radiotherapy

Effects of Ionizing Radiation in Cancer Radiotherapy

Hardcover

Medical ReferenceBiologyChemistry

ISBN10: 3725833869
ISBN13: 9783725833863
Publisher: Mdpi AG
Published: Mar 14 2025
Pages: 214
Weight: 1.49
Height: 0.69 Width: 6.69 Depth: 9.61
Language: English

For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This targeted effect (TE) model has been questioned by numerous observations, in which cells, that were not directly irradiated, exhibited responses similar to those of directly irradiated cells. Therefore, it is now accepted that the detrimental effects of ionizing radiation are not restricted only to irradiated cells, but also to non-irradiated adjacent or distant cells.

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