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Drug Safety Evaluation: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 1641
ISBN13: 9781493971701
Publisher: Humana Pr
Published: Jul 27 2017
Pages: 427
Weight: 2.15
Height: 1.00 Width: 7.00 Depth: 10.00
Language: English
1. Nonclinical Development of Combination Drugs
Alberto Lodola
2. Juvenile Non-Clinical Safety Studies in Support of Pediatric Drug Development
Paul C. Barrow and Georg Schmitt
Part II: Pathology
3. Procedures of Necropsy and Tissue Sampling
Laurence Fiette, Mohamed Slaoui, and Anne-Laure Bauchet
4. Tissue Sampling and Processing for Histopathology Evaluation
Mohamed Slaoui, Anne-Laure Bauchet, and Laurence Fiette
5. Principles and Methods of Immunohistochemistry
José A. Ramos-Vara
6. Applications of Mass Spectrometry Imaging for Safety Evaluation
David Bonnel and Jonathan Stauber
Part III Genetic Toxicology
7. In vivo rat T-lymphocyte Pig-a assay: detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene
Vasily N Dobrovolsky, Javier Revollo, Dayton M Petibone, and Robert H Heflich
8. Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids
Takafumi Kimoto and Daishiro Miura
9. The Use of Bacterial Repair Endonucleases in the Comet Assay
Andrew R. Collins
Part IV Safety Pharmacology
10. Automated Patch-Clamp methods for the hERG Cardiac Potassium Channel
Sylvie Houtmann, Brigitte Schombert, Camille Sanson, Michel Partiseti, and G. Andrees Bohme
11. Impedance Measurement in Induced Pluripotent Stem Cell Derived Cardiomyocytes
Emma-Jane Poulton
Part V Investigative Toxicology
12. Target Safety Assessment: Strategies and Resources
Richard J. Brennan
13. NMR and MS Methods for Metabolomics
Alexander Amberg, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Frank Dieterle, and Matthias Keck
14. Protocols and Applications of Cellular Metabolomics in Safety Studies Using
Precision-Cut Tissue Slices and Carbon 13 NMR
Gabriel Baverel, Maha El Hage, and Guy Martin
15. Statistical Analysis of Quantitative RT-PCR Results
Richard Khan-Malek and Ying Wang
16. Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes
Jean-Pierre Marchandeau and Gilles Labbe
Part VI Screening Assays for Developmental Toxicity
17. FETAX Assay for Evaluation of Developmental Toxicity
Isabelle Mouche, Laure Malésic, and Olivier Gillardeaux
18. Evaluation of Embryotoxicity Using
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