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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and Covid-19

Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and Covid-19

Byun, Wan Gi

Hardcover

Series: Springer Theses

BiologyChemistry

ISBN10: 9811978131
ISBN13: 9789811978135
Publisher: Springer Nature
Published: Dec 14 2022
Pages: 128
Weight: 0.90
Height: 0.16 Width: 5.98 Depth: 9.13
Language: English

This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19.

Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

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