Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Dynamics, Binding and Function of Intrinsically Disordered Proteins

Dynamics, Binding and Function of Intrinsically Disordered Proteins

Ramsey, Rudyard

Hardcover

Medical ReferenceBiology

ISBN10: 1646465717
ISBN13: 9781646465712
Publisher: Foster Academics
Published: Sep 19 2023
Pages: 254
Weight: 1.95
Height: 0.63 Width: 8.50 Depth: 11.00
Language: English
Intrinsically disordered proteins (IDPs) are a class of proteins that do not fold into a specific three-dimensional structure, which is a characteristic of proteins. The structural flexibility of IDPs range from fully structured to partially structured, which enables them to complement ordered proteins in order to perform functions that cannot be performed by rigid structures. Several factors such as pH and temperature can affect the shape and level of disorder in proteins. IDPs have been associated with various diseases such as cancer and cardiovascular diseases. The accumulation of an IDP called α-synuclein plays a pathophysiological role in Parkinson's disease (PD). The structural flexibility of the unstructured α-synuclein protein and associated disease mechanisms is affected by several factors such as genetics, oxidative stress, nitrative stress, and mitochondrial impairment. The book aims to shed light on some of the unexplored aspects of intrinsically disordered proteins and the recent researches on them. It will serve as a valuable source of reference for the graduate and postgraduate students.

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