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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Clinical Pharmacology in the Elderly: Reference Ranges and Biological Variations After Repeated Measurements

Clinical Pharmacology in the Elderly: Reference Ranges and Biological Variations After Repeated Measurements

Kuhlmann, J.
Breuel, Hans-Peter
Heine, P. R.

Paperback

Medical Reference

ISBN10: 3540594957
ISBN13: 9783540594956
Publisher: Springer
Published: Dec 1 1995
Pages: 182
Weight: 0.61
Height: 0.41 Width: 6.14 Depth: 9.21
Language: English
The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma- cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude ....: ''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.

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