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Camptothecins in Cancer Therapy

Camptothecins in Cancer Therapy

Paperback

Series: Cancer Drug Discovery & Development

Medical Reference

ISBN10: 1627038167
ISBN13: 9781627038164
Publisher: Springer Nature
Published: Nov 15 2014
Pages: 460
Weight: 1.46
Height: 0.96 Width: 6.14 Depth: 9.21
Language: English
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.

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Medical Reference