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Cytokine Storm Syndrome

Cytokine Storm Syndrome

Paperback

Medical Reference

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ISBN10: 3030220966
ISBN13: 9783030220969
Publisher: Springer
Published: Sep 20 2020
Pages: 617
Weight: 1.95
Height: 1.29 Width: 6.14 Depth: 9.21
Language: English

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.

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